Radiotherapy to the brain: what are the consequences of this age-old treatment?

: Radiotherapy (RT) has been widely used in the management of benign and malignant brain tumors for decades. However, complications can develop as a result adjacent structures being exposed to radiation. As such, careful selection patients deciding on most suitable modality RT are crucial minimize complications. In general, be subdivided based its timeline onset; acute (few days weeks), early delayed (1–6 months) late (>6 months). Late such cognitive decline radiation necrosis debilitating negatively impacts quality-of-life. New strategies reduce RT-related with hippocampal sparing-WBRT, memantine, focal (e.g., stereotactic radiosurgery) have had promising results adopted clinical practice. This review will focus brain, WBRT or SRS-related adverse events, well measures mitigate these